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Frequently Asked Questions

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Depression (by Alvin E. Lake III, PhD)


What is Depression?

In everyday language we use the word "depressed" to describe a wide range of feelings. At one end are brief periods of unhappiness that we all experience at times, often in reaction to loss or unmet expectations. At the other end lie profound feelings of hopelessness, where a person may feel life is not worth living. In contrast to these common perspectives, clinical depression can occur without feelings of sadness, and can be of significant concern even when the depressed person has hope for the future.

There are three basic types of clinical depression: major depressive disorder, dysthymic disorder, and bipolar disorder. Major depression is marked by either a depressed mood or loss of interest in most things for a period of at least two weeks. These feelings represent a distinct change from normal experience, and are accompanied by at least four of the following symptoms: the depressed person may lose appetite and weight; eat excessively and gain weight; sleep too much or too little; feel agitated or fatigued; experiences difficulty with thinking, concentrating, or decision making; have a sense of enduring worthlessness or guilt; and in some cases have recurrent thoughts of death or suicide.

Dysthymic disorder is a low-grade depression with negative mood and/or chronic irritability, combined with at least two of the following: poor appetite or overeating, sleep disturbance, low energy, low self-esteem, poor concentration or indecision, or feelings of hopelessness. This type of depression may start early in life and persist for a long time. The diagnosis requires that symptoms be present for at least one year in adolescents, and two years or more in adults. The mood disturbance may come to be experienced as if it were part of the sufferer's normal personality.

Bipolar disorders are characterized by mood swings. Periods of elevated, energetic, or irritable mood alternate with bouts of depression. The distinctive "highs" may last for a few hours to over a week, and are referred to as hypomanic or manic episodes depending on their severity and duration. The diagnosis requires at least three additional symptoms, such as inflated self-esteem or grandiosity, decreased need for sleep (e.g. less than three hours), talking excessively, racing thoughts, distractibility, or increased goal-directed activity. In some cases the individual may engage in activities with a high potential for serious adverse consequences: spending large amounts of money for unneeded items, driving recklessly, or engaging in risky and promiscuous sexual activity.

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How common is depression?

Based on scientific community surveys in the United States, 7.0% of women and 2.6% of men will experience at least one episode of major depression in their lifetime. Lifetime rates of dysthymic disorder are similar: 4.1% of women and 2.2% of men. Bipolar disorders are less common, with a lifetime prevalence of 1.2% for both men and women.

There is an increased risk of major depression in migraine sufferers, between 3.1 and 3.6 times the rate for those without migraine. For example, a recent survey of over 1000 young adults in the Detroit area found that 34.4% of those with migraine had at least one major depressive episode, compared to 10.4% for those without migraine. In most cases (54.5%), the migraine headaches preceded depression by at least a year. For 30% depression came first, and 15.5% reported the onset of both disorders in the same year.

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What causes depression?

At its core, depression is a biological event influenced by genetics and biochemistry. The neurotransmitters serotonin and norepinephrine play an important role in both migraine and depression. Epidemiological survey research suggests that the migraine-depression connection may reflect a distinct genetically-based syndrome that differs from migraine without depression. In major depression, early episodes are often triggered by significant life stress, although repeated episodes later in life may occur without apparent triggers. There is some evidence suggesting a role for early life events such as trauma, significant losses, or hostile, negative environments, which in turn have a biological impact on the brain of a growing child. A family history of alcoholism also increases the risk for depression.

Depression is also affected by the way we think. When depressed, people are more likely to focus on the negative, view stressful events as catastrophes, see things in black or white terms, and blame themselves for events for which they are not fully responsible. Some view depression as a weakness, blaming themselves or others for failing to pull out of it by a sheer force of will. This type of distorted thinking then adds further fuel to the depression in a vicious cycle.

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Is depression primarily a psychological reaction to the pain or disability of migraine?

There is no question that unremitting, severe headaches can be depressing, and that depression often improves when pain is controlled. However, not all patients with similar levels of headaches suffer depression. Sometimes depression remains a significant concern even when headaches are no longer a problem.

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How is depression treated?

Most studies show a combination of antidepressant medication and psychological treatment (focused on coping skills and enhancing interpersonal relationships) as the most effective treatment for depression. Cognitive-behavioral psychotherapy, which addresses the relationship between thoughts (cognitions), feelings, and behavior has been shown in controlled research studies to be particularly helpful in both improving depression and preventing relapse. MHNI psychologists can help clarify the diagnosis of depression, often assist in the choice of antidepressant medication, and provide a supportive environment for learning about depression and the necessary skills to cope with it. At MHNI, patients have the unique opportunity to work in close collaboration with psychologists and medical doctors to treat both headache and depression.

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