 Research
Headache disorders (for example, migraine, cluster, tension-type) and other pain
and neurological disorders are being explored by clinicians, scientists, and the
pharmaceutical industry with renewed vigor. This is to the great advantage of those
of us who experience headache/pain or care for or about headache/pain sufferers.
There is now a better understanding
of the anatomy and physiology of
the brain and the complex mechanisms of headache
and other painful disorders. The role of neurotransmitters (norepinephrine, serotonin,
etc.), inflammation, blood vessels, muscles, among others, are all being examined.
A number of available medications,
presently being used for other illnesses, are being studied for possible application
to the treatment of headache and pain. These include anticonvulsants, anti-inflammatory
agents, antidepressants, and medications from other pharmaceutical groups used alone
or in combination.
The pharmaceutical industry is concentrating
research efforts on the development of new compounds designed specifically for the
treatment of headache and other pain disorders. Each is aimed at the neurochemical
source of the pain process to arrest an attack at its onset or to prevent attacks
altogether. In addition, innovative delivery systems (nasal sprays, inhalers, skin
patches, autoinjectors, etc.) are being perfected to more efficiently and effectively
deliver headache and pain medications.
Large-scale surveys are being performed
to detail the impact of headache and pain on individuals, their families, employers,
and society at large. Studies on prevalence, effect on quality of life, loss of
work time, and health care costs have shed new light on the enormity of the issue
of pain.
Consistent with its mission, MHNI
is actively involved in a wide range of clinical research projects. These include
studies on investigational medications and devices, program outcome data, and better
ways to assess and evaluate patients in pain. Participants in research projects
come from MHNI's own patient population, referrals from local physicians, and outreach
into local communities and nearby states.
If you would like more information
about headache and pain research, please contact the Research Division of MHNI at
(734) 677-6000, option 4, or contact us directly through this web site.
Marjorie E. Winters, R.N.
Director of Pharmaceutical Research
Michigan Headache & Neurological Institute
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